Iowa Territory is formed, including in its claim present-day Minnesota west of the Mississippi River, which was called Clayton County. Henry H. Sibley serves as justice of the peace for the county, but this part of Minnesota would be left without a government when Iowa became a state in 1846.

Light rail service between the Minneapolis and St. Paul downtowns begins. Called the Green Line, the eleven-mile line passes through the University of Minnesota campus and along University Avenue.

A massive storm, which continues into June 20, drops over seven inches of rain on Duluth and surrounding areas. 3,100 homes and businesses are damaged. Total damage estimates are set at $100 million. Floodwaters overwhelm the Duluth Zoo, killing several animals and leading several others to escape. The Swinging Bridge in Jay Cooke State Park is destroyed.

Light rail service on the Blue Line, between downtown Minneapolis and Fort Snelling, begins. Full service to MSP Airport and the Mall of America begins on December 4, 2004. Through the end of 2013, there are 90.5 million rides on the Blue Line.

William James Mayo is born in Le Sueur. As an adult he joined the medical practice of his father, William Worrall Mayo, leading to the creation with his brother Charles of the Mayo Clinic.

A four-day event celebrating the Norse-American Centennial begins at the Minnesota State Fair Grounds in Falcon Heights.

The K. J. Taralseth Company building is a physical reminder of the early commercial development of Warren. After moving from a brick store that was destroyed by fire in 1910, Ralph Taralseth built a new store that reflected the company's success. The new building carried a mixed product line for which the company became known. It also provided space for the professional services and fraternal organizations forming in and around Warren.

Bert D. Keck was an architect who moved to Crookston, Minnesota, in 1902. His Neo-classical and Romanesque designs for Crookston’s costliest and most significant public buildings changed the skyline of the town. Three of his structures are listed on the National Register of Historic Places.

In 1904, along Portage Lake, in a birch-bark-and-cattail wigwam, a baby named Naawakamigookwe (Middle of the Earth Woman, also called Maude) was born to Agwadaashiins (Nancy Pine) and Gwayoonh (Charles Mitchell). She took her first breath in the traditional Ojibwe home of her family. It was the beginning of a life guided by cultural traditions, continuous adaptation to a fast-changing world, and an inherent skill for interpreting her people’s culture and history.

A trustbuster, senator, secretary of state, Nobel laureate, and World Court judge, Frank Kellogg rose from a small farm in Olmsted County to being the highest-ranking diplomat in the United States. He is remembered as one of the authors of the 1928 Pact of Paris, a multi-lateral treaty that renounced aggressive war as a matter of national policy.

Kenesseth Israel (Assembly of Israel) is the oldest Orthodox Jewish congregation in Minnesota. Founded in 1891, it was the first congregation on Minneapolis' North Side.