Charles Joseph Biederman of Red Wing, an influential and non-conformist American Modernist painter, sculptor and art theorist, made a lasting mark in American and international art circles.

Organized at Fort Snelling in the fall of 1861, the Third Minnesota Veteran Volunteer Infantry Regiment was unique. The third-largest Minnesota infantry unit, it had the most men die of disease (239) and the third-highest number of deserters (most of them prisoners of war who returned to service by 1863). It also had the most men promoted as officers into United States Colored Troop units (eighty-two), making it one of the top ten sources of USCT officers. Noted for their discipline and hardiness, the men of the Third twice repulsed cavalry charges while in line of battle rather than in a bayonet-armed square formation.

One of the first female professors in the United States, Maria Sanford was an English professor at the University of Minnesota for nearly thirty years. Her exceptional teaching, notable public lectures, and active community leadership led many to call her "the best-loved woman in Minnesota."

By the 1970s, Red Wing's famed Main Street scarcely resembled its 1870s glory days. But Red Wing was revitalized in the following decades by the vision and initiative of the Red Wing Shoe Company's William D. Sweasy.

Minnesota State Senator Anton J. Rockne took pride in the nickname "Watchdog of the State Treasury." Yet as America's Great Depression deepened in 1932, he fought against programs for the poor and his opponents branded him "Commander-in-Chief of the Hunger Brigade."

Samuel Bloomer served in Company B of the First Minnesota Volunteer Infantry Regiment during the Civil War. He was the regiment's color sergeant, and after the war was deeply involved in civic life and the Grand Army of the Republic.

Eugenie Moore Anderson emerged as a trailblazer for American women in international diplomacy during the post-World War II era. In 1949 she became the first American woman to hold the rank of ambassador.

Adam Marty was a member of the First Minnesota Volunteer Infantry Regiment during the Civil War. After the war he became Commander of the Minnesota Department of the Grand Army of the Republic (GAR).

The fate of the Union army hung in the balance on the second day of the Battle of Gettysburg in 1863. Confederate soldiers punched a hole in its defenses and only the men of the First Minnesota Infantry, led by Colonel William Colvill, stood in their way.

After New York City schoolteacher Harriet Duncan came to Minnesota in 1868, she became an advocate for temperance and women's suffrage. She was president of the Minnesota Woman's Christian Temperance Union (WCTU) for seventeen years and urged the WCTU to work on behalf of women's rights more broadly.