The First Minnesota Volunteer Infantry Regiment holds a special place in the history of Minnesota. It was the first body of troops raised by the state for Civil War service, and it was among first regiments of any state offered for national service.

With its lavishly illustrated seed catalogs and store displays, Northrup, King and Company became a household name at the turn of the twentieth century. The company sold hardy, Northern-grown garden seed before expanding into Northern field seed and plant hybrids.

During the mid-to-late nineteenth century, Minnesota faced public health issues such as poor sanitation and disease epidemics. To address these issues, Minnesota established a state board of health in 1872. It was the third such board in the United States.

At the turn of the twentieth century, Minneapolis became a national center for the arts movement known as Arts and Crafts. The city's Handicraft Guild led the way. Founded by women, the Handicraft Guild made the arts in Minneapolis more democratic and populist by offering classes like pottery and metalwork to artists and teachers.

In 1878, businessmen Henry A. Bruns and Henry G. Finkle built the first steam-powered grain elevator in the Red River Valley. In its first harvest season, the elevator handled almost 250,000 bushels of wheat from more than 5,000 wagons.

Tired of ethnic discrimination as well as dangerous working conditions, low wages, and long work days, immigrant iron miners on the Mesabi Range in northeastern Minnesota went on strike on July 20, 1907. It was the first organized strike on the state's Iron Range.