In 1868, the grain trade in Minnesota was growing, but few railroads existed in the state. Steamboats were the supreme mode of transportation. William Robinson built a grain warehouse on the banks of the Mississippi to take advantage of the steamboat traffic. Shortly afterward the town of Jefferson was plotted. In a few years, however, the railroad came through, and a larger town was platted to the south. The Jefferson Grain Warehouse quickly became obsolete.

The Father Louis Hennepin Bridge was built in 1855 to take advantage of the transport possibilities provided by the Mississippi River above St. Anthony Falls. It was the first bridge built to span the Mississippi river, and made crossing its length above the Falls much easier. The rushing rapids helped to create industry on the river and spurred a population boom that made Minneapolis the most populated city in Minnesota.

Built in 1867, the Chubb House is the oldest residence standing in Fairmont, and the only of the town's houses known to have been built with brick from Fairmont's first brickyard. It was the home of prominent homesteader Orville Chubb, who was the community's first physician. The house is an example of a property associated with the early Yankee American development of southern Minnesota town sites.

Charlotte Ouisconsin Clark Van Cleve was the child of a military family and a crusader for the rights of disadvantaged people in Minnesota and beyond. Born during her parents' journey to help build the future Fort Snelling, she lived to see a fledgling community grow into an urban center.

The last in a series of violent conflicts between Dakota and Ojibwe people took place on the banks of the Minnesota River north of the village of the Dakota leader Shakpedan (Little Six) on May 27, 1858. Dozens of Ojibwe and Dakota warriors engaged in fighting that claimed lives on both sides but produced no clear victor.

The Harrington-Merrill House is the oldest wood-framed structure in Hutchinson and one of the oldest in McLeod County. Lewis Harrington was one of Hutchinson's founders. Harry Merrill, who served as superintendent of schools for thirty-three years, was likely the most important educator in the town's history.

Joseph Rolette was a fur trader and politician during Minnesota's territorial period. A colorful character in his time, Rolette is remembered for the drastic action he took to prevent the removal of Minnesota's capital to St. Peter.

On February 22, 1854, the Chicago and Rock Island Railroad completed the first rail line to connect the Mississippi River to the Atlantic Ocean. To promote that feat the company contacted notable East Coast citizens and journalists and invited them to ride their train to Rock Island. From there, the visitors took a steamboat trip up the Mississippi, stopping at St. Paul. The journalists, pleased with what they saw, wrote of the beauty and splendor of a region that many in the East thought was little more than a wilderness.

Recruited in the fall of 1861, Brackett's Battalion served longer than any other Minnesota unit during the Civil War. After campaigning in the Western Theater, the Battalion participated in the Northwestern Indian Expeditions of 1864 and 1865.

The Faribault Woolen Mill Company has statewide significance as one of the largest and oldest fully integrated woolen mills in Minnesota. The mill started as a small family-owned business in the nineteenth century and grew to become the largest and longest-surviving woolen mill in the state.