Roy Wilkins, who spent his formative years in the Twin Cities, led the National Association for the Advancement of Colored People (NAACP) from 1949 to 1977. During those years, the NAACP helped achieve the greatest civil rights advancements in U.S. history. Wilkins favored new laws and legal challenges as the best ways for African Americans to gain civil rights.

The US–Dakota War of 1862 was a turning point in Minnesota history. Joseph Godfrey, an enslaved man, joined the Dakota in their fight against white settler-colonists that summer and fall. He was one of only two African Americans to do so.

Fur trader and translator George Bonga was one of the first Black people born in what later became the state of Minnesota. His mother was Ojibwe, as were both of his wives. Through these relationships, Bonga was part of the mixed racial and cultural groups that connected trading companies and Native Americans. He frequently guided white travelers and traders through the region. Comfortable in many worlds, Bonga often worked as an advocate for the Ojibwe in their dealings with trading companies and the United States government.