Two of Duluth's oldest Jewish congregations—Temple Emanuel and Tifereth Israel—had little in common after they were founded in the 1890s. While Temple Emanuel was affiliated with Reform Judaism, Tifereth Israel conducted worship services in the Orthodox tradition. Tifereth Israel's 1945 shift to Conservative Judaism, however, coupled with the decline of Duluth's Jewish population, led the two congregations to unite in 1969 as Temple Israel.

Minnesota's worst known encounter with smallpox came in 1924 and 1925. Five hundred people died—four hundred of them in the Twin Cities. Almost 90 percent of the Twin Cities deaths took place in Minneapolis.

When Adas Israel Congregation was founded, in 1885, by Lithuanian immigrants, members met in a house on St. Croix Avenue in what is now the Canal Park area of Duluth. It incorporated in 1899.

The Minnesota State Public School for Dependent and Neglected Children operated from 1886 to 1947. The campus is one of the most intact examples of a state cottage school standing in the United States, and is significant on a national level.

In 1910 there were over sixty orphanages and homes for the aged operated by and for African Americans in the United States. Minnesota had one of them: St. Paul's Crispus Attucks Home. The home was named for the African American patriot killed in the Boston Massacre of 1770. It served the community for six decades, beginning in 1906 during the Jim Crow era and ending in 1966 at the peak of the civil rights movement.

One of nearly a dozen early Orthodox Jewish congregations in North Minneapolis, Tifereth B'nai Jacob was founded by immigrants from Bessarabia. The congregation served the community for seventy years before merging with other synagogues and moving to St. Louis Park.

The Faribault Woolen Mill Company has statewide significance as one of the largest and oldest fully integrated woolen mills in Minnesota. The mill started as a small family-owned business in the nineteenth century and grew to become the largest and longest-surviving woolen mill in the state.

Sharei Chesed (Gates of Kindness or Splendor) is a Conservative Jewish congregation in Minnetonka. It was created in 1969 when two North Minneapolis Orthodox congregations merged. They were Sharei Zedeck (Gates of Righteousness) and Gemelus Chesed (Providing Kindness).

The world's most iconic home thermostat was created in Minneapolis. The Round, designed by engineer Carl Kronmiller and designer Henry Dreyfuss, was introduced in 1953 by the company then known as Minneapolis-Honeywell. The Round became both a sales mainstay and a world-renowned piece of industrial art.

Kenesseth Israel (Assembly of Israel) is the oldest Orthodox Jewish congregation in Minnesota. Founded in 1891, it was the first congregation on Minneapolis' North Side.