John Sayer was a trader, a merchant, and a partner in several fur trade companies for more than thirty years. In the late 1790s, he became a partner of the North West Company and proprietor of their Fond du Lac district, supervising trade with the Ojibwe south of Lake Superior and west across what is now northern Minnesota.

Seth Eastman was a painter and soldier best known for his depictions of the everyday life of Dakota and Ojibwe people around Fort Snelling in the 1840s. He stands out among other nineteenth-century American artists—particularly those who also painted American Indian people—because of his commitment to realism. Unlike his peers, Eastman mostly avoided romanticizing the Native people with whom he lived.

Albert Alonzo Ames, called “Doc,” was mayor of Minneapolis four times, between 1876 and 1903. Though he earned notoriety as "the shame of Minneapolis" for his involvement in extortion and fraud during his last term in office, Ames also won praise for his work as a doctor and an advocate for veterans.

Vincent Raymond (V. R.) Dunne dedicated his life to improving the plight of workers. A leader in the 1934 Minneapolis Teamsters strike and convicted in the Smith Act Trial of 1941 for his involvement in the Socialist Workers Party, Dunne fought many battles in labor and politics.

Frances Andrews worked as an advocate for social justice, education, and conservation in the early twentieth century. She called for preservation of the forests and lakes that became the Boundary Waters Canoe Area Wilderness and experimented with land restoration in northwestern Wisconsin. Her legacy includes an endowment that continues to support social and environmental causes in the 2010s.

Conservative lawyer John F. McGee was the dominant personality on the Minnesota Commission of Public Safety, the body that governed Minnesota during World War I. Under McGee’s leadership, the commission demanded unquestioning support for the war effort and suppressed possible German American dissent. After the war, McGee became a federal judge who was well known for the heavy sentences he imposed on bootleggers.

At the turn of the twentieth century, Evangeline Whipple used her wealth to improve the lives of women, people of color, and the poor. She supported social justice for Native Americans in Minnesota, for African Americans in Florida, and for villagers and World War I refugees in Bagni di Lucca, Italy.

Senator Eugene McCarthy challenged President Lyndon Johnson for the 1968 Democratic nomination, mobilizing a youth crusade against U.S. intervention in Vietnam and changing the course of politics in Minnesota and the nation.

Douglas Volk was an American painter and arts educator. He was the founding director of the Minneapolis School of Arts and provided two paintings to the Minnesota State Capitol.

Elof Wedin was a Swedish-born Minnesota painter active from the 1920s to the 1970s and best known for his abstract geometric style.