Famed author and lecturer Charles Eastman (Ohiyesa) was raised in a traditional Dakota manner until age fifteen, when he entered Euro-American culture at his father's request. He spent the rest of his life moving between Native American and white American worlds, achieving renown but never financial security.

In the 1850s and 60s, Thomas Barlow (T. B.) Walker worked his way through school and into Minnesota's lumber industry, where he became unusually successful. He later helped found two of Minneapolis's significant cultural organizations: the public library system and the Walker Art Center.

While working at Minneapolis's Washburn mills in the late 1870s, William de la Barre became an internationally known hydroelectricity expert and a key player in the development of water power at St. Anthony Falls.

Thomas Lowry was one of the most influential and admired men in Minneapolis at the time of his death in 1909. Streetcars, railroads, libraries, and many other endeavors benefited from his involvement.

Sometimes known as the "Father of the Skyscraper," Leroy Sunderland Buffington was a prolific architect who had a lasting impact on the built environment of Minneapolis. In the 1880s, Buffington was nationally known. His architectural office employed more than thirty draftsmen, making it the largest in the region.

Charles Alfred Pillsbury was one of Minnesota's most prominent millers. His Minneapolis company, Charles A. Pillsbury and Co., was among the largest milling firms in the world during the last decades of the nineteenth century.